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Tesofensine 250mcg/cap 60 Capsules & Semaglutide 6mg Bundle
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Where to buy Tesofensine Capsules & Semaglutide 6mg? Shop now for Tesofensine Capsules & Semaglutide 6mg with exceptional quality and get more for less with our bulk sales. Quick 48-hour delivery available.
- Receipt and Inspection: Upon receiving Semaglutide and Tesofensine peptides in capsule form from our trusted supplier network, we perform a preliminary quality check to ensure the product meets baseline specifications.
- Purity and Assay Testing: Before products are listed for sale, they undergo third-party purity testing to confirm the percentage of the active compound and assay testing to verify the compound’s concentration.Purity Testing: Determines the level of impurities or contaminants in the peptide, ensuring it meets research-grade standards.
Assay Testing: Confirms the compound’s chemical composition and potency, verifying its suitability for experimental use. - Testing Methods: Our testing partners use advanced analytical techniques, including:
- High-Performance Liquid Chromatography (HPLC): Analyzes purity by separating and quantifying individual components in the peptide.
- Mass Spectrometry (MS): Identifies the molecular structure and verifies the peptide’s identity.
- Fourier Transform Infrared Spectroscopy (FTIR): Confirms the peptide’s chemical bonds and functional groups.
- Nuclear Magnetic Resonance (NMR): Provides detailed structural analysis of the peptide.
- Approval for Sale: After these tests return positive results, we list Semaglutide 6mg and Tesofensine peptides in capsules and vials on our site for purchase. This ensures you receive validated research-grade products that you can trust for your experiments. Lab tests are occasionally published on the website.
- Sterile Water for Injection:
Preferred for single-use applications, sterile water ensures purity and minimizes contamination risks. It’s commonly used in studies requiring a single administration. - Bacteriostatic Water (BAC Water):
Containing 0.9% benzyl alcohol, BAC water helps prevent bacterial growth, making it ideal for studies requiring multiple administrations over several days or weeks. Researchers value its stability for extended research. BAC water is included as a gift with any peptide vial purchase.
Properties
Tesofensine 250mcg/cap
Chemical Formula: C17H23Cl2NO
Molecular Mass: 328.3
Synonyms: NS-2330, UNII-BLH9UKX9V1, BLH9UKX9V1, ZINC3953158
CAS Number: 195875-84-4
PubChem:11370864
Total Amount of the Active Ingredient: 250mcg/cap 60 capsules (1 bottle)
Shelf Life: 36 months
Semaglutide 6mg
Chemical Formula: C187H291N45O59
Molecular Weight: 4144g/mol
Synonyms: Semaglutide; NN9535; 910463-68-2; UNII-53AXN4NNHX; NN 9535
PubChem: 56843341
CAS#: 910463-68-2
Total Amount of the Active Ingredient: 6mg (1 vial)
Shelf Life: 36 months
Uncompromising Quality Assurance for Tesofensine Capsules & Semaglutide Bundle
At Triggered Brand, we are dedicated to providing researchers with high-purity peptides like Semaglutide and Tesofensine, available in capsules, that meet the strictest quality standards. Products listed on our site are also available in vials and undergo a rigorous quality control process to ensure reliability and consistency for your research.
Scientific literature
Weight loss produced by Tesofensine in patients with Parkinson’s or Alzheimer’s disease
Abstract
Objective: Tesofensine (TE) is a norepinephrine, dopamine, and serotonin reuptake inhibitor. We conducted a meta-analysis of TE’s effect on body weight in trials investigating its potential for treatment of Parkinson’s or Alzheimer’s disease.
Methods and procedures: Four randomized, double-blind, multicenter trials compared TE (n = 740) and placebo (n = 228), two in each disease. Patients received oral TE or placebo once daily for 14 weeks without any weight loss program. Results were adjusted for baseline values, age, and study.
Results: In the placebo group, 14% were obese and 21% were in the TE group. In the total cohort, weight change after 14 weeks was +0.5, -0.5, -0.9, -1.8, -2.8% in the placebo, 0.125, 0.25, 0.5 and 1.0 mg in the TE groups, respectively (P = 0.015 for dose effect). In the obese subgroup, weight changes were -0.2, -1.7, -1.6, -1.5, -3.7%, and 2.1, 8.2, 14.1, 20.9, 32.1% of the obese patients achieved > or = 5% weight loss (P < 0.001 for 0.25, 0.5, and 1.0 mg vs. placebo for both end points). Changes in heart rate were -0.4, 2.1, 4.2, 6.0, and 6.8 bpm after 14 weeks (TE vs. placebo: P < 0.001 from 0.25 mg), but no effect on blood pressure was observed.
Discussion: TE produced a placebo-subtracted weight loss of approximately 4% for >14 weeks without any diet and lifestyle therapy, which is similar to that of sibutramine, but with no effect on blood pressure. On the basis of these results, TE is now being developed for obesity management.
Abstract
Tesofensine is a novel monoamine reuptake inhibitor that inhibits both norepinephrine, 5-HT, and dopamine (DA) reuptake function. Tesofensine is currently in clinical development for the treatment of obesity, however, the pharmacological basis for its strong effect in obesity management is not clarified. Using a rat model of diet-induced obesity (DIO), we characterized the pharmacological mechanisms underlying the appetite suppressive effect of tesofensine. DIO rats treated with tesofensine (2.0 mg/kg, s.c.) for 16 days showed significantly lower body weights than vehicle-treated DIO rats, being reflected by a marked hypophagic response. Using an automatized food intake monitoring system during a 12 h nocturnal test period, tesofensine-induced hypophagia was investigated further by studying the acute interaction of a variety of monoamine receptor antagonists with tesofensine-induced hypophagia in the DIO rat. Tesofensine (0.5-3.0 mg/kg, s.c.) induced a dose-dependent and marked decline in food intake with an ED(50) of 1.3 mg/kg. The hypophagic response of tesofensine (1.5 mg/kg, s.c.) was almost completely reversed by co-administration of prazosin (1.0 mg/kg, alpha(1) adrenoceptor antagonist) and partially antagonized by co-administration of SCH23390 (0.03 mg/kg, DA D(1) receptor antagonist). In contrast, tesofensine-induced hypophagia was not affected by RX821002 (0.3 mg/kg, alpha(2) adrenoceptor antagonist), haloperidol (0.03 mg/kg, D(2) receptor antagonist), NGB2904 (0.1 mg/kg, D(3) receptor antagonist), or ritanserin (0.03 mg/kg, 5-HT(2A/C) receptor antagonist). Hence, the mechanism underlying the suppression of feeding by tesofensine in the obese rat is dependent on the drug’s ability to indirectly stimulate alpha(1) adrenoceptor and DA D(1) receptor function.
Abstract
Background: Tesofensine (TE) is a new drug producing twice the weight loss in obese individuals as seen with currently marketed drugs. It inhibits the presynaptic reuptake of the neurotransmitters noradrenaline, dopamine and serotonin, and is thought to enhance the neurotransmission of all three monoamines. The mechanisms by which it produces weight loss in humans are unresolved.
Objective: The aim of this study is to investigate the mechanism(s) behind weight reduction by measuring energy expenditure and appetite sensations in overweight and obese individuals.
Design: Thirty-two healthy, overweight or moderately obese men were treated with 2.0 mg TE daily for 7 days followed by an additional 7 days with 1.0 mg TE daily or corresponding placebo (PL) in a randomized, controlled trial. They were instructed to maintain habitual food intake and physical activity throughout. Twenty-four-hour energy expenditure (24-h EE), fat oxidation and spontaneous physical activity were measured in a respiration chamber before and after treatment. Body composition was assessed by dual-energy X-ray absorption and appetite was evaluated by visual analogue scales in conjunction with a standardized dinner.
Results: Despite efforts to keep body weight and composition constant, TE induced a 1.8 kg weight loss above PL after 2 weeks’ treatment (P<0.0001). TE also induced higher ratings of satiety and fullness and concomitantly lower prospective food intake than placebo. No significant effect of TE on total 24-h EE could be demonstrated compared with PL, but higher energy expenditure was observed during the night period (4.6%; P<0.05) when adjusted for changes in body composition. Furthermore, TE increased 24-h fat oxidation as compared with PL (18 g; P<0.001).
Conclusion: TE has a pronounced effect on appetite sensations and a slight effect on energy expenditure at night-both effects can contribute to the strong weight-reducing effect of TE.
Semaglutide|Tesofensine: Dosing and Mixing for Research
Understanding the Format: Vial
Semaglutide is available in a single vials 2mg, 6mg, 11mg, 22mg, as well as bundles to save you money: Semaglutide 2mg|AOD9604 2mg, Semaglutide 6mg|AOD9604 5mg, Semaglutide 6mg|MOTs-C 5mg, Tesofensine Capsules|Semaglutide 6mg, Tesofensine Capsules|Semaglutide 6mg|AOD9604 5mg.
Tesofensine is available in a single bottle Tesofensine Capsules, as well as bundles for you to get on sale: Tesofensine Capsules|Semaglutide 6mg, and Tesofensine Capsules|Semaglutide 6mg|AOD9604 5mg.
These are designed for flexibility in research studies requiring precise preparation and mixing. These formats allow researchers to control mixing solutions and customize protocols according to their study needs.
Mixing Semaglutide Vials
Proper preparation ensures research accuracy and consistency. Researchers typically use one of the following solutions for mixing:
Understanding Dosing for Semaglutide|Tesofensine Bundle
When conducting research with Semaglutide 6mg Vials|Tesofensine 250mcg Capsules, it is crucial to recognize that dosing parameters vary based on the specific objectives and design of each research study. Research compounds, including Tesofensine|Semaglutide, are intended strictly for in vitro testing and laboratory experimentation purposes and are not approved for human consumption.
In accordance with legal and regulatory guidelines, we cannot provide dosing guidance or recommendations for Semaglutide 6mg Peptide Vials|Tesofensine 250mcg Capsules. Providing such advice would violate compliance laws, as it could be interpreted as prescribing usage for research studies.
This product is not a drug, food, or cosmetic and must not be introduced into humans or animals under any circumstances. It should only be handled by licensed, qualified professionals in a controlled research environment.
For information regarding dosing, researchers are encouraged to consult peer-reviewed studies or other reputable scientific sources relevant to their field of study.
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Disclaimer
The information provided above is not intended to substitute medical advice, diagnosis, or treatment. Should you have any questions regarding a medical condition, seek the advice of your physician or a qualified healthcare provider. In no case should medical advice be disregarded or delayed because of what you have read or seen. We bear no responsibility or liability for your use of any of our research compounds and products. Please note that they are being sold for research purposes ONLY. We do NOT condone any personal use.
Note: In some cases wherein the assigned top colors are out of stock, a different top color will be used to ensure that your order will not be delayed. Should you need assistance identifying the peptide vial that you received, please send us an email at [email protected].
ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.
The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: “in glass”) are performed outside the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat and/or cure any medical condition, ailment or disease. Bodily introduction of any kind into animals or human is strictly prohibited by law.
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| How Many Bundles? | 1 Bundle, 2 Bundles, 3 Bundles, 4 Bundles, 5 Bundles, 10 Bundles, 20 Bundles, 40 Bundles, 100 Bundles |
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FAQ
Tesofensine 250mcg/cap 60 Capsules
How to dose Tesofensine 250mcg/ Capsules?
The dosing of Tesofensine 250mcg/ Capsules in capsule form will vary according to the experiment being conducted. We do not provide dosage recommendations as our products are intended for research purposes only.
When to administer Tesofensine 250mcg/ Capsules?
There are multiple methods of administering research products and timing of administration methods that are under investigation in various studies. The choice of administration technique should align with the specific goals and design of the researcher’s study. We provide products solely for research use, we do not offer advice on administration methods.
Semaglutide 6mg Vials
How to reconstitute Semaglutide 6mg vials?
Semaglutide 6mg vials contain a peptide powder, which is typically a puck or loose bits due to shipping. To reconstitute a Semaglutide 6mg vials, researchers typically use bacteriostatic water, combining it with the peptide powder according to the specific requirements of their research protocols.
How to dose Semaglutide 6mg?
The dosing of Semaglutide 6mg in vials form will vary according to the experiment being conducted. We do not provide dosage recommendations as our products are intended for research purposes only.
How to administer Semaglutide 6mg?
There are multiple methods of administering research products that are under investigation in various studies. The choice of administration technique should align with the specific goals and design of the researcher’s study. We provide products solely for research use, we do not offer advice on administration methods.
This is the extra content added to the product description.
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