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PT141 10mg
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PT-141, also called Bremelanotide (generic clinical name), is a heavily modified synthetic derivative of alpha-melanocyte-stimulating hormone. It has been tested in clinical trials as a treatment for both male/female hypoactive sexual desire disorder and acute hemorrhage. PT-141 is an agonist for the melanocortin-4 and melanocortin-1 receptors. Research shows that it promotes sexual arousal and stimulates the immune system.
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- Purity Testing: Determines the level of impurities or contaminants in the product, ensuring it meets research-grade standards.
- Assay Testing: Confirms the compound’s chemical composition and potency, verifying its suitability for experimental use.
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- High-Performance Liquid Chromatography (HPLC): Analyzes purity by separating and quantifying individual components in the compound.
- Mass Spectrometry (MS): Identifies the molecular structure and verifies the compound’s identity.
- Fourier Transform Infrared Spectroscopy (FTIR): Confirms the compound’s chemical bonds and functional groups.
- Nuclear Magnetic Resonance (NMR): Provides detailed structural analysis of the compound.
- Sterile Water for Injection:
Preferred for single-use applications, sterile water ensures purity and minimizes contamination risks. It’s commonly used in studies requiring a single administration. - Bacteriostatic Water (BAC Water):
Containing 0.9% benzyl alcohol, BAC water helps prevent bacterial growth, making it ideal for studies requiring multiple administrations over several days or weeks. Researchers value its stability for extended research. BAC water is included as a gift with any peptide vial purchase.
Properties
PT141 10mg
Chemical Formula: C50H68N14O10
Molecular Mass: 1025.182g/mol
Synonyms: PT-141; bremelanotide acetate, PT 141
CAS Number: 189691-06-3
PubChem: 9941379
Total Amount of the Active Ingredient: 10 mg (1 vial)
Shelf Life: 36 months
Uncompromising Quality Assurance for PT-141
At Triggered Brand, we are dedicated to providing researchers with high-purity PT141 that meets the strictest quality standards. Products listed on our site undergo a rigorous quality control process to ensure reliability and consistency for your research.
1. Receipt and Inspection: Upon receiving PT141 from our trusted supplier network, we perform a preliminary quality check to ensure the product meets baseline specifications.
2. Purity and Assay Testing: Before products are listed for sale, they undergo third-party purity testing to confirm the percentage of the active compound and assay testing to verify the compound’s concentration.
3. Testing Methods: Our testing partners use advanced analytical techniques, including:
4. Approval for Sale: After these tests return positive results we list PT141 10mg on our site for purchase. This ensures you receive validated research-grade products that you can trust for your experiments. Lab tests are occasionally published on the website.
Scientific literature
Bremelanotide for the Treatment of Hypoactive Sexual Desire Disorder
Abstract
Bremelanotide significantly improves sexual desire and related distress in premenopausal women with hypoactive sexual distress disorder and has a favorable safety profile.
OBJECTIVE:
To evaluate the safety and efficacy of bremelanotide for the treatment of premenopausal women with hypoactive sexual desire disorder.
METHODS:
Two identical phase 3, randomized, double-blind, placebo-controlled, multicenter clinical trials (RECONNECT) evaluated the safety and efficacy of bremelanotide 1.75 mg administered subcutaneously as needed in premenopausal women with hypoactive sexual desire disorder. Patients were randomized 1:1 to 24 weeks of treatment with bremelanotide or placebo. Sample size was estimated based on simulations from key endpoints in patients with hypoactive sexual desire disorder from a prior trial. Coprimary efficacy endpoints were change from baseline to end-of-study in the Female Sexual Function Index–desire domain score and Female Sexual Distress Scale–Desire/Arousal/Orgasm item 13.
RESULTS:
Study 301 began on January 7, 2015, and concluded on July 26, 2016. Study 302 began on January 28, 2015, and concluded on August 4, 2016. Of the 1,267 women randomized, 1,247 and 1,202 were in the safety and efficacy (modified intent-to-treat) populations, respectively. Most participants were white (85.6%), from U.S. sites (96.6%), and had a mean age of 39 years. From baseline to end-of-study, women taking bremelanotide had statistically significant increases in sexual desire (study 301: 0.30, P<.001; study 302: 0.42, P<.001; integrated studies 0.35, P<.001) and statistically significant reductions in distress related to low sexual desire (study 301: −0.37, P<.001; study 302: −0.29, P=.005; integrated studies −0.33, P<.001) compared with placebo. Patients taking bremelanotide experienced more nausea, flushing, and headache (10% or more in both studies) compared with placebo.
CONCLUSIONS:
Both studies demonstrated that bremelanotide significantly improved sexual desire and related distress in premenopausal women with hypoactive sexual desire disorder. The safety profile was favorable. Most treatment-emergent adverse events were related to tolerability and the majority were mild or moderate in intensity.
Abstract
Introduction
Melanocortins affect multiple physiological responses, including sexual behaviors. Bremelanotide is a synthetic peptide melanocortin analog of α‐melanocyte‐stimulating hormone that is an agonist at melanocortin receptors MC3R and MC4R.
Aim
To evaluate a single intranasal dose of bremelanotide for potential effects on physiological and subjective measurements of sexual arousal and desire in premenopausal women with sexual arousal disorder.
Main Outcome Measures
Change in vaginal pulse amplitude during neutral and erotic videos after treatment with bremelanotide or placebo and subjects’ perceptions of physiological and sexual response within 24 hours of treatment with bremelanotide or placebo.
Methods
Eighteen premenopausal women with a primary diagnosis of female sexual arousal disorder were randomly assigned to receive a single intranasal dose of 20 mg bremelanotide or matching placebo in a double‐blind manner during the first in‐clinic treatment session, and the alternate medication during the second in‐clinic treatment session. During each session, subjects viewed a 20‐minute neutral video followed by a 20‐minute sexually explicit video. Vaginal photoplethysmography was used to monitor vaginal vasocongestion and questionnaires were used to evaluate perceptions of sexual response within the following 24‐hour period.
Results
More women reported moderate or high sexual desire following bremelanotide treatment vs. placebo (P = 0.0114), and a trend toward more positive responses regarding feelings of genital arousal occurred after bremelanotide compared with placebo (P = 0.0833). Among women who attempted sexual intercourse within 24 hours after treatment, significantly more were satisfied with their level of sexual arousal following bremelanotide, compared with placebo (P = 0.0256). Vaginal vasocongestion did not change significantly while viewing erotic videos following bremelanotide administration compared with placebo.
Conclusion
This preliminary evaluation suggests the potential for bremelanotide to positively affect desire and arousal in women with female sexual arousal disorder and indicates that bremelanotide is a promising candidate for further evaluation in an at‐home study. Diamond LE, Earle DC, Heiman JR, Rosen RC, Perelman MA, and Harning R. An effect on the subjective sexual response in premenopausal women with sexual arousal disorder by bremelanotide (PT‐141), a melanocortin receptor agonist. J Sex Med 2006;3:628–638.
PT-141: a melanocortin agonist for the treatment of sexual dysfunction
Abstract
PT-141, a synthetic peptide analogue of alpha-MSH, is an agonist at melanocortin receptors including the MC3R and MC4R, which are expressed primarily in the central nervous system. Administration of PT-141 to rats and nonhuman primates results in penile erections. Systemic administration of PT-141 to rats activates neurons in the hypothalamus as shown by an increase in c-Fos immunoreactivity. Neurons in the same region of the central nervous system take up pseudorabies virus injected into the corpus cavernosum of the rat penis. Administration of PT-141 to normal men and to patients with erectile dysfunction resulted in a rapid dose-dependent increase in erectile activity. The results suggest that PT-141 holds promise as a new treatment for sexual dysfunction.
PT141: Dosing and Mixing for Research
Understanding the Format: Vial
PT141 is available in a single vials 10mg these are designed for flexibility in research studies requiring precise preparation and mixing. These formats allow researchers to control mixing solutions and customize protocols according to their study needs.
Mixing PT141 Vials
Proper preparation ensures research accuracy and consistency. Researchers typically use one of the following solutions for mixing:
Understanding Dosing for PT141
When conducting research with PT-141 10mg Peptide Vials, it is crucial to recognize that dosing parameters vary based on the specific objectives and design of each research study. Research compounds, including PT141, are intended strictly for in vitro testing and laboratory experimentation purposes and are not approved for human consumption.
In accordance with legal and regulatory guidelines, we cannot provide dosing guidance or recommendations for PT141 10mg Vial. Providing such advice would violate compliance laws, as it could be interpreted as prescribing usage for research studies.
This product is not a drug, food, or cosmetic and must not be introduced into humans or animals under any circumstances. It should only be handled by licensed, qualified professionals in a controlled research environment.
For information regarding dosing, researchers are encouraged to consult peer-reviewed studies or other reputable scientific sources relevant to their field of study.
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Disclaimer
The information provided above is not intended to substitute medical advice, diagnosis, or treatment. Should you have any questions regarding a medical condition, seek the advice of your physician or a qualified healthcare provider. In no case should medical advice be disregarded or delayed because of what you have read or seen. We bear no responsibility or liability for your use of any of our research compounds and products. Please note that they are being sold for research purposes ONLY. We do NOT condone any personal use.
Note: In some cases wherein the assigned top colors are out of stock, a different top color will be used to ensure that your order will not be delayed. Should you need assistance identifying the peptide vial that you received, please send us an email at [email protected].
ALL ARTICLES AND PRODUCT INFORMATION PROVIDED ON THIS WEBSITE ARE FOR INFORMATIONAL AND EDUCATIONAL PURPOSES ONLY.
The products offered on this website are furnished for in-vitro studies only. In-vitro studies (Latin: “in glass”) are performed outside the body. These products are not medicines or drugs and have not been approved by the FDA to prevent, treat and/or cure any medical condition, ailment or disease. Bodily introduction of any kind into animals or human is strictly prohibited by law.
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| How Many Vials? | 1 Vial, 2 Vials, 3 Vials, 4 Vials, 5 Vials, 10 Vials, 20 Vials, 40 Vials, 100 Vials |
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FAQ
PT-141 10mg Vials
How to reconstitute PT-141 10mg vials?
PT-141 10mg vials contain a peptide powder, which is typically a puck or loose bits due to shipping. To reconstitute a PT-141 10mg vials, researchers typically use bacteriostatic water, combining it with the peptide powder according to the specific requirements of their research protocols.
How to dose PT-141 10mg?
The dosing of PT-141 10mg in vials form will vary according to the experiment being conducted. We do not provide dosage recommendations as our products are intended for research purposes only.
How to administer PT-141 10mg?
There are multiple methods of administering research products that are under investigation in various studies. The choice of administration technique should align with the specific goals and design of the researcher’s study. We provide products solely for research use, we do not offer advice on administration methods.
This is the extra content added to the product description.
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